PDRN stands for polydeoxyribonucleotide. It is a purified extract of DNA fragments derived from salmon. It has been studied for its ability to promote tissue repair, reduce inflammation, and stimulate collagen production in the skin.

Is salmon DNA the same as "salmon sperm facial"?

Yes, they refer to the same treatment. PDRN is extracted from salmon reproductive cells and purified for medical use. The clinical name is PDRN or polynucleotide therapy. "Salmon sperm facial" is a colloquial term popularized by media coverage of the treatment.

How is PDRN different from PRP or exosomes?

PRP uses your own blood platelets to promote healing. Exosomes use cell-signaling molecules. PDRN works differently by activating specific cell receptors (adenosine A2A) that trigger your skin's own regenerative processes. Some patients combine these treatments for complementary benefits.

Is PDRN FDA-approved?

Injectable PDRN has not been approved by the U.S. Food and Drug Administration for cosmetic use. It is widely used in clinical settings outside the U.S. and is offered at medical spas under physician oversight. Topical PDRN products are regulated as cosmetics.

Is the treatment safe?

PDRN has been used in clinical wound-healing applications for over a decade. All treatments at Cienega Medical are performed by licensed providers under medical direction. A consultation is required to review your health history and determine if PDRN is appropriate for you. Common side effects may include temporary redness or mild swelling at the treatment site.

Can I get PDRN if I have a fish allergy?

PDRN is derived from salmon, so this treatment is not recommended for individuals with known fish or fish-product allergies. Please discuss any allergies with your provider during your consultation.

How many sessions will I need?

Most providers recommend a series of 3 to 4 treatments spaced 3 to 4 weeks apart for best results. After the initial series, maintenance treatments every 3 to 6 months can help sustain improvements. Your provider will recommend a plan based on your skin goals.

When will I see results?

Initial improvements in hydration and skin texture may be noticeable within 2 to 3 weeks. More significant changes in firmness and fine lines typically develop over 4 to 6 weeks as collagen production increases.

Is there any downtime?

Downtime is minimal. You may experience mild redness or slight swelling for a day or two after treatment. Most patients return to normal activities the same day.

Can PDRN be combined with other treatments?

Yes. PDRN is commonly paired with microneedling, facials, or other skin treatments to enhance results. Your provider can recommend the best combination for your goals during your consultation.

Cienega Medical

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Salmon DNA (PDRN) Treatment

Regenerative Skin Rejuvenation with PDRN

Regenerative facial treatment using purified polynucleotides

★★★★★ 3,356 Five-Star Reviews

30-45 min per session

Minimal Downtime resume same day

3-4 Sessions recommended

Book a Free Consultation

Price FAQ

16+ Years

3 Locations

7 Days Open

What to Expect

Injectable Regenerative No Anesthesia Required

Meet with your provider to discuss your skin goals and determine whether PDRN is the right fit for you.

Your provider applies or administers PDRN to the treatment area in a comfortable clinical setting.

Skin improvements develop gradually as collagen production increases. Most patients see best results after a series of treatments.

IDEAL FOR

Is PDRN Right for You?

You may be a good candidate for PDRN treatment if:

You want to improve overall skin quality and hydration

You are looking for a treatment with minimal downtime

You want to complement other treatments like microneedling or facials

You are interested in a regenerative approach rather than filler or toxins

You have no known allergy to fish or fish-derived products

PDRN is not recommended for individuals with fish allergies. A consultation with your provider is required before treatment.

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Patient Reviews

★★★★★ 3,356 Five-Star Reviews

across all locations

Alizeh W.

West Hollywood

★★★★★

"Let's start with the fact that I've been to MANY med spas all over the state. I drove to LA because honestly just don't get anything done in San Francisco ever. Less experienced and more expensive in Northern California.I made an appointment online but called to confirm and ... was super helpful over the phone and gave me the best tip on where to get a fast Covid test.The moment I walked in, everyone treated me like a friend. ... was so fun AND professional about taking my temperature and laughing at my off the wall jokes about my sagging old lady skin.I didn't know what I needed and what to get so they set me up in a cute room where ... (MY NEW BFF) came and went over exactly what I wanted and the options to get there. I have never had an experience like this where I really felt heard and not pushed into something. She explained the difference between every single option just like a best friend over coffee. I never felt pressure to do anything that I didn't understand.The nurse ... came in to make sure I was medically cleared and that extra level of care is reassuring. Everyone was masked and gloved and very particular about cleanliness and safety.We agreed that to get the most out of my day in LA, I should get the package of 8 treatments. If we didn't use it all on my old saggy face, I could try cool sculpting! ... ran my care credit card and I saved $1,800 on the actual retail price. No fuss and ready to get started! I'm so impressed they could even make time for all my procedures.I have redhead problems where I don't get numb and everything makes me cry. ... totally understood and went above and beyond to make sure I was comfortable.I had no idea Ultherapy could lift brows! She was clear it might be uncomfortable but honestly it barely felt warm and tingly. ... even came in to show me her brow as she had a great experience using it. It felt like everyone there was just as excited as my best friends would be for me.... is a genuinely sweet person but also an absolute artist! She very skillfully injected this here giant baby with every kind of filler in every place. We laughed together when some things didn't hurt and she reassured when I was struggling with a little pain. Best filler experience EVER!She found just the right amount of different kinds of filler so I could try cool sculpting on my stomach with the last of my treatments. The room was so comfy and cozy. It didn't hurt and I kinda forgot I wasn't in my bed watching TV! Their bed was more comfortable than my bed at the W...Yes I woke up swollen all over because maybe 8 treatments is a little much but I had some Advil and went about my life. There is not a bruise or red mark on my face. I have totally bruised in the past from similar treatments but not here. My boyfriend just said I looked great when I got home with no idea why. I told him because I'm a loud mouth and couldn't wait to show him the before and after photos. He said I look just like pictures he had seen of my younger self from before we met.PRICE: Yes you can get filler cheaper than $750 per syringe but by buying the package, all my treatments we $525 each which is totally reasonable. Umm get Coolscupting or Ultherapy for that price anywhere else? No you probably cannot. Also I've had some bad filler for cheap that needed to be redone or dissolved later so what's the savings in that? Also I don't care what any of these reviews say about tipping nurses, TIP PEOPLE WHO GIVE GREAT SERVICE!There's tons of Med Spas in LA but none like this. Just put your face in ...'s hands and you'll be so happy. I'll be back ASAP for Pixel and maybe Emsculpt! Much love to the whole team."

Verified review →

Danielle M.

West Hollywood

★★★★★

"What an amazing experience! I came to them after a summer of going to the beach with minimal sunscreen! From the moment I walked in everyone was super sweet! ... is AMAZING! She's literally a skin guru! I came in specifically for the texture of my skin. I did my own research ahead of time and knew what I wanted. When I met with ... she actually steered me in a direction of skincare and not just a "quick fix" she went over everything with me and just asked me to trust her and the process. I'm so glad I did! After being sent home with quite a few products ... sent a follow up email on what to and how to use each product. She also responded to any and every email I sent with follow up questions. I stuck the course and just came for a 7 week follow up and the texture of my skin has completely changed! My skin was so dull with pigment issues before and now just naturally glows. I'm on an continued journey of skincare and look forward to the next follow up in another 6 or so weeks! If you're looking for professional skincare this place is amazing. Everyone is so nice and truly there to help you look and feel your best! If you want to see before and after it's on ...'s Instagram page @skinguruLA"

Verified review →

Neil Flores

West Hollywood

★★★★★

"Love Cienega Med spa! ... at the front desk was so sweet, welcoming, and professional. ..., my injector, did my microneedling and was amazing kind, gentle, and knowledgeable. Both of them made me feel completely comfortable and taken care of. Highly recommend!"

Verified review →

What Can PDRN Help With?

PDRN may help improve the appearance of:

Fine lines and wrinkles

Dull or uneven skin tone

Dry or dehydrated skin

Loss of skin firmness

Rough or uneven texture

Post-procedure skin recovery

Results vary by individual. Your provider will help set realistic expectations during your consultation.

Important Information

PDRN (polydeoxyribonucleotide) treatments have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) for cosmetic use. This treatment is not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Individual outcomes depend on factors including skin type, age, and overall health.

All PDRN treatments at Cienega Medical are performed under the direction of our medical team. A consultation is required before any treatment to determine if you are a suitable candidate.

What Is Salmon DNA (PDRN)?

PDRN (polydeoxyribonucleotide) is a regenerative skin treatment derived from purified salmon DNA fragments. It works by activating your body’s natural repair processes to improve skin hydration, texture, and firmness from within. Unlike fillers that add volume or lasers that create controlled injury, PDRN signals your skin cells to behave as they did when they were younger, stimulating collagen production and improving blood flow to the treatment area.

PDRN treatments have been used in clinical settings for wound healing and tissue repair for over a decade, and are now one of the most sought-after facial rejuvenation options at medical spas across the country.

How Much Does Salmon DNA (PDRN) Treatment Cost?

Select your treatment below and book a time that works for you. Booking is free and just holds your spot. Your provider will confirm the right option at your appointment. You can reschedule or cancel online anytime.

Skincare Consultation | FREE

Not sure what to choose or want to meet us before you decide? Choose this option for a free, no obligation consultation to meet with one of our skincare experts.

How PDRN Works

PDRN activates adenosine A2A receptors in your skin, which triggers a cascade of regenerative effects: reduced inflammation, new blood vessel formation, and activation of fibroblasts (the cells responsible for collagen production). The result is improved skin quality from the cellular level up, not just on the surface.

FAQ

What is PDRN?
PDRN stands for polydeoxyribonucleotide. It is a purified extract of DNA fragments derived from salmon. It has been studied for its ability to promote tissue repair, reduce inflammation, and stimulate collagen production in the skin.
Is salmon DNA the same as "salmon sperm facial"?
Yes, they refer to the same treatment. PDRN is extracted from salmon reproductive cells and purified for medical use. The clinical name is PDRN or polynucleotide therapy. "Salmon sperm facial" is a colloquial term popularized by media coverage of the treatment.
How is PDRN different from PRP or exosomes?
PRP uses your own blood platelets to promote healing. Exosomes use cell-signaling molecules. PDRN works differently by activating specific cell receptors (adenosine A2A) that trigger your skin's own regenerative processes. Some patients combine these treatments for complementary benefits.
Is PDRN FDA-approved?
Injectable PDRN has not been approved by the U.S. Food and Drug Administration for cosmetic use. It is widely used in clinical settings outside the U.S. and is offered at medical spas under physician oversight. Topical PDRN products are regulated as cosmetics.
Is the treatment safe?
PDRN has been used in clinical wound-healing applications for over a decade. All treatments at Cienega Medical are performed by licensed providers under medical direction. A consultation is required to review your health history and determine if PDRN is appropriate for you. Common side effects may include temporary redness or mild swelling at the treatment site.
Can I get PDRN if I have a fish allergy?
PDRN is derived from salmon, so this treatment is not recommended for individuals with known fish or fish-product allergies. Please discuss any allergies with your provider during your consultation.
How many sessions will I need?
Most providers recommend a series of 3 to 4 treatments spaced 3 to 4 weeks apart for best results. After the initial series, maintenance treatments every 3 to 6 months can help sustain improvements. Your provider will recommend a plan based on your skin goals.
When will I see results?
Initial improvements in hydration and skin texture may be noticeable within 2 to 3 weeks. More significant changes in firmness and fine lines typically develop over 4 to 6 weeks as collagen production increases.
Is there any downtime?
Downtime is minimal. You may experience mild redness or slight swelling for a day or two after treatment. Most patients return to normal activities the same day.
Can PDRN be combined with other treatments?
Yes. PDRN is commonly paired with microneedling, facials, or other skin treatments to enhance results. Your provider can recommend the best combination for your goals during your consultation.