The Immune-Defense Peptide

LL-37

Discuss skin and immune-health concerns with a nurse practitioner.

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3 Locations
Open 7 Days
16 Years in Business

How It Works

  1. Decide which peptide you think is right for you. Not sure which one? Our nurse will help you choose.
  2. Link up with us on the phone or video. Pick a time with our nurse, then fill out a short health form (about 10 minutes). If it’s right for you, you can get your prescription the same day, on the call.
  3. Get the product shipped to your house, or pick it up in the store. Then we’ll discuss the best way for you to get it, whether you pick it up at our clinic or have it shipped to your house at no extra charge.

LL-37: $199

Your telehealth visit is free. If you buy, we add a $49 medication review for your prescription.

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Nothing to pay to book. California residents only.

How Much Does LL-37 Cost?

Every order adds one $49 medication review. Free delivery anywhere in California, or pick it up at any clinic.

Is LL-37 Right for You?

LL-37 is prescription-only and considered after a provider reviews your situation.

People focused on immune and skin-barrier support

Anyone dealing with slow-healing skin issues alongside standard care

Clients building a provider-guided plan

Book a free consultation with our medical team to see if it is appropriate.

What LL-37 Is Studied For

LL-37 is a naturally occurring 37-amino-acid peptide and part of the body’s first-line immune defense. Research has examined its antimicrobial activity, its role in regulating inflammation, and its involvement in wound healing, including wounds that are slow to close. It is a research peptide, prescription-only.

First-line antimicrobial defense

Regulation of the inflammatory response

Wound healing, including stubborn or chronic wounds

What the Research Shows

LL-37 is part of the body’s own natural defenses. Swedish scientists first reported it in 1995. Most research is lab and animal work, and human trials are few.

1995, Lab Study (PNAS)

Scientists found the gene for this peptide in human bone marrow, first naming it FALL-39. A lab-made version was highly active against two kinds of bacteria in lab tests.
1995 study on PubMed

2021, 148 Patients With Leg Ulcers (Wound Repair and Regeneration)

In 148 patients with hard-to-heal leg ulcers, LL-37 applied to the wound didn’t improve healing overall compared with placebo. It was well tolerated.
2021 study on PubMed

2024, Review (Antibiotics)

A review describes LL-37’s role in skin defense and wound repair, and notes that many peptide drugs have failed in trials because of unclear benefit and safety concerns.
2024 review on PubMed

LL-37 is not FDA-approved for any use. These studies don’t show that it treats any condition in people, and safety data in people are limited. Your free consultation with a nurse practitioner is the place to talk through what is and isn’t known.

Important Information

Most peptides are not FDA-approved for the uses discussed publicly, and are prescribed at the discretion of a licensed provider after an individual evaluation. A peptide is not appropriate for everyone, and individual results vary.

Peptide therapy at Cienega Medical is available by prescription only. You start with a consultation with one of our nurse practitioners, who reviews your health history, your goals, and whether a peptide is appropriate for you. If it is, they write the prescription and we prepare it for your visit. If it is not, they will tell you that too.

What Is LL-37?

LL-37 is a peptide the human body produces naturally, thirty-seven amino acids long, and it belongs to a family called cathelicidins that form part of the innate immune system, the body’s built-in first line of defense. Its studied roles include disrupting bacterial cell membranes, helping regulate the inflammatory response, and supporting wound healing. Because it is part of the body’s own defenses, researchers have looked at it in the context of chronic wounds and infections that are slow to heal. Most of that work is laboratory and early-stage rather than large human trials. It is not approved by the FDA for any use.

FAQ

  • What is LL-37, and what is it studied for?

    LL-37 is a naturally occurring antimicrobial peptide in the cathelicidin family, part of the innate immune system. Researchers have studied its role in bacterial cell membranes, inflammatory signaling and wound healing, including work on chronic wounds and gut and skin conditions. Human research is mostly early, with much of what is known coming from laboratory work rather than large, long-term human trials. Your nurse practitioner can discuss that research in relation to your concerns at the free consultation.

  • Is LL-37 FDA-approved?

    No. LL-37 is not approved by the FDA for any use. It is prescribed at the discretion of a licensed provider following an individual evaluation, starting with a free nurse practitioner consultation.

  • What are the risks of LL-37, and who should avoid it?

    LL-37 is not right for everyone. Your nurse practitioner reviews your health history, current medications and any existing conditions before prescribing and will tell you if it is not a fit. Bring your current medication list to your free consultation.

  • What does it cost, and what is included?

    Bottle prices are listed on this page. Every order includes one medication review fee, which covers the review and managing your prescriptions, and is charged once even when prescriptions go out as separate orders the same day. The consultation itself is free.

  • How do I start?

    Pick a time for a free telehealth visit with a nurse practitioner, by phone or video. Before your visit, you fill out a short health form. They go through your health history, your current medications and what you are trying to achieve, then tell you whether this is a sensible fit. Not everyone is, and if you are, they write the prescription and you pay for your bottles plus one medication review fee.

  • Where does my prescription come from?

    Your prescription is filled by a licensed U.S. 503A compounding pharmacy.

  • How long does a bottle last, and how do refills work?

    That depends on what your provider prescribes, so it is not something we can put a number on here. Your nurse practitioner tells you at your review roughly how long a bottle should last for you and when it would make sense to order again. You can order as many bottles as your nurse prescribes while you’re on the call, and when you need more, book another call online or call us. Each call where you order adds one $49 medication review. Nothing renews on its own. If you’d like bottles sent on a regular schedule, ask your nurse: it’s worked out case by case, since everyone’s prescription is different.

  • Can I collect it or have it shipped?

    Both. Collect at West Hollywood, Santa Monica or Calabasas, where we pack it for you and show you how to inject it, all covered by the medication review fee. Or we ship it to your home anywhere in California, at no extra charge.

3 Locations In Los Angeles

Open Daily; Including Sundays

Modern medical spa lobby with marble desk, green plant ceiling, and sage green walls.
Calabasas
26787 Agoura Rd
Calabasas, CA 91302
(310) 341-2776 Location details →
Modern med spa lobby with a colorful rainbow mural, white reception desk, and a wooden surfboard on a blue wall.
Santa Monica
902 Broadway
Santa Monica, CA 90401
(310) 307-3617 Location details →
Modern medical spa reception with a green wall, floral goddess mural, neon sign, and gold ring chandelier.
West Hollywood
375 N. La Cienega Blvd
West Hollywood, CA 90048
(323) 992-0090 Location details →

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