The Energy & Metabolism Peptide

MOTS-c

Take Control of Your Energy

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3 Locations
Open 7 Days
16 Years in Business

How It Works

  1. Decide which peptide you think is right for you. Not sure which one? Our nurse will help you choose.
  2. Link up with us on the phone or video. Pick a time with our nurse, then fill out a short health form (about 10 minutes). If it’s right for you, you can get your prescription the same day, on the call.
  3. Get the product shipped to your house, or pick it up in the store. Then we’ll discuss the best way for you to get it, whether you pick it up at our clinic or have it shipped to your house at no extra charge.

MOTS-c: $99

Your telehealth visit is free. If you buy, we add a $49 medication review for your prescription.

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Nothing to pay to book. California residents only.

Prescribed here. Filled by a pharmacy.

By Phone

Our nurse calls you at the time you pick, wherever you are in California. Pick it up at Calabasas, Santa Monica or West Hollywood, or have it shipped home.

Filled by a Licensed Pharmacy

Your prescription is filled by a licensed U.S. 503A pharmacy.

Prescription Only

Nothing is dispensed without a prescription from our medical team.

How Much Does MOTS-c Cost?

Every order adds one $49 medication review. Free delivery anywhere in California, or pick it up at any clinic.

Is MOTS-c Right for You?

MOTS-c is prescribed after a consultation. People ask about it mainly for metabolism and energy rather than a specific condition.

Adults focused on metabolic health and steady energy

Active people supporting endurance and recovery

Anyone taking a healthy-aging approach with a provider

Book a free consultation with our medical team to talk it through.

What MOTS-c Is Studied For

MOTS-c is unusual: it is a sixteen-amino-acid peptide encoded not in the cell nucleus but in mitochondrial DNA, the DNA inside the structures that make cellular energy. It is often described as an exercise-mimetic because research links it to how the body uses fuel. Interest centers on metabolism, energy, and healthy aging. It is a research peptide, prescription-only.

Metabolic flexibility and how the body burns fuel

Insulin sensitivity and glucose handling

Fat oxidation and energy production

Athletic performance and healthy aging

What the Research Shows

MOTS-c was discovered in Los Angeles, at USC, in 2015. Most of what is known so far comes from cell and animal studies.

2015, Mice (Cell Metabolism)

The study that named MOTS-c. In mice, it prevented the insulin resistance that comes with age and with a high-fat diet, and it prevented diet-induced weight gain. Its main target appeared to be skeletal muscle.
2015 study on PubMed

2021, Mice, Plus Exercise in People (Nature Communications)

MOTS-c improved physical performance in young, middle-aged and old mice. In people, exercise raised the body’s own MOTS-c in muscle and blood; that doesn’t show a benefit from taking it.
2021 study on PubMed

2026, Review (Sports Medicine)

A review of peptides sold for recovery and performance, MOTS-c included, found favorable results in animal studies but little rigorous safety data in people.
2026 review on PubMed

MOTS-c is not FDA-approved for any use. These studies don’t show that it treats any condition in people, and safety data in people are limited. Your free consultation with a nurse practitioner is the place to talk through what is and isn’t known.

Important Information

Most peptides are not FDA-approved for the uses discussed publicly, and are prescribed at the discretion of a licensed provider after an individual evaluation. A peptide is not appropriate for everyone, and individual results vary.

Peptide therapy at Cienega Medical is available by prescription only. You start with a consultation with one of our nurse practitioners, who reviews your health history, your goals, and whether a peptide is appropriate for you. If it is, they write the prescription and we prepare it for your visit. If it is not, they will tell you that too.

What Is MOTS-c?

MOTS-c is a short peptide, sixteen amino acids long, that is unusual in where it comes from: it is encoded not in the DNA of the cell nucleus but in the separate DNA carried inside mitochondria, the structures that produce energy within cells. It was identified relatively recently, in 2015, and researchers have studied it mainly in relation to metabolism, insulin sensitivity, and how cells respond to exercise. Most of the research so far has been in cell and animal models, and it is an active area of study. MOTS-c is a research peptide, available at Cienega by prescription only.

FAQ

  • What is MOTS-c, and what is it studied for?

    MOTS-c is a peptide of sixteen amino acids encoded in mitochondrial DNA rather than in the cell nucleus. Researchers have studied it mainly in relation to metabolism and insulin sensitivity, sometimes calling it an exercise mimetic because of how it behaves in laboratory models. The human research is very little so far, mostly cell and animal models rather than large human trials, which your nurse practitioner can put in context at your free consultation.

  • Is MOTS-c FDA-approved?

    No. MOTS-c is not approved by the FDA for any use.

  • What are the risks of MOTS-c, and who should avoid it?

    MOTS-c is not right for everyone. Your nurse practitioner reviews your health history, current medications and any existing conditions before prescribing and will tell you if it is not a fit. Bring your current medication list to your free consultation.

  • What does it cost, and what is included?

    Bottle prices are listed on this page. Every order includes one medication review fee, which covers the review and managing your prescriptions, and is charged once even when prescriptions go out as separate orders the same day. The consultation itself is free.

  • How do I start?

    Pick a time for a free telehealth visit with a nurse practitioner, by phone or video. Before your visit, you fill out a short health form. They go through your health history, your current medications and what you are trying to achieve, then tell you whether this is a sensible fit. Not everyone is, and if you are, they write the prescription and you pay for your bottles plus one medication review fee.

  • Where does my prescription come from?

    Your prescription is filled by a licensed U.S. 503A compounding pharmacy.

  • How long does a bottle last, and how do refills work?

    That depends on what your provider prescribes, so it is not something we can put a number on here. Your nurse practitioner tells you at your review roughly how long a bottle should last for you and when it would make sense to order again. You can order as many bottles as your nurse prescribes while you’re on the call, and when you need more, book another call online or call us. Each call where you order adds one $49 medication review. Nothing renews on its own. If you’d like bottles sent on a regular schedule, ask your nurse: it’s worked out case by case, since everyone’s prescription is different.

  • Can I collect it or have it shipped?

    Both. Collect at West Hollywood, Santa Monica or Calabasas, where we pack it for you and show you how to inject it, all covered by the medication review fee. Or we ship it to your home anywhere in California, at no extra charge.

3 Locations In Los Angeles

Open Daily; Including Sundays

Modern medical spa lobby with marble desk, green plant ceiling, and sage green walls.
Calabasas
26787 Agoura Rd
Calabasas, CA 91302
(310) 341-2776 Location details →
Modern med spa lobby with a colorful rainbow mural, white reception desk, and a wooden surfboard on a blue wall.
Santa Monica
902 Broadway
Santa Monica, CA 90401
(310) 307-3617 Location details →
Modern medical spa reception with a green wall, floral goddess mural, neon sign, and gold ring chandelier.
West Hollywood
375 N. La Cienega Blvd
West Hollywood, CA 90048
(323) 992-0090 Location details →

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Serving LA since 2010 · 3,356 five-star reviews

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